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Recombinant Cavia Porcellus CD152/CTLA-4 Protein, His Tag

Protein

Recombinant Cavia Porcellus CD152/CTLA-4 Protein, His Tag

  • Expression Host: Yeast
  • Species: Cavia Porcellus
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD152

CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) is a Protein Coding gene. Diseases associated with CTLA4 include Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation and Celiac Disease 3. Among its related pathways are Gene expression (Transcription) and CD28 co-stimulation. An important paralog of this gene is CD28.Inhibitory receptor acting as a major negative regulator of T-cell responses.The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. 

 

Alpha Lifetech follows strict quality control principles to ensure that our recombinant proteins meet standards of purity, efficacy, and consistency.

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Product Background

Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin(Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

Product Specification

Catalog Number

ALP64648

Product Name

Recombinant Cavia Porcellus CD152/CTLA-4 Protein, His Tag

Alias

Cytotoxic T-lymphocyte protein 4, CD152

Alternate Names

cd152,ctla4 cd152,ctla-4,ctla-4 inhibitors,ctla-4 inhibitor,ctla-4 receptor,ctla-4 gene,ctla-4 ligand,ctla-4 signaling pathway,ctla-4 expression,ctla-4 signaling,ctla-4 cancer, ctla-4 pathway,Recombinant Protein,cd152 protein,ctla-4 protein,Cavia Porcellus CD152 Protein,his tag,his tag protein

Official Symbol

CD152/CTLA-4

Species

Cavia Porcellus

Expression Host

Yeast

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64648 Recombinant Cavia Porcellus CD152 Protein, His Tag is produced in Yeast and the target gene encoding Ala37-Asp161 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Krummel, M. F., and Allison, J. P., The Journal of Experimental Medicine, 1996, DOI: 10.1084/jem.183.6.2533

2 Chambers, C. A., et al.,Immunological Reviews, 1999, DOI: 10.1111/j.1600-065X.1999.tb01339.x

3 Walunas, T. L., et al., Immunity, 1994, DOI: 10.1016/1074-7613(94)90144-9

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