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Recombinant Cynomolgus Monkey CD223/LAG3 Protein, Fc Tag

Protein

Recombinant Cynomolgus Monkey CD223/LAG3 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Cynomolgus Monkey
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD223

LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. Diseases associated with LAG3 include Kyphoscoliotic Heart Disease and Endocervical Carcinoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and MHC class II protein binding. An important paralog of this gene is IL1RAPL1.Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells.Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity).FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity).

 

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Product Background

Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.

Product Specification

Catalog Number

ALP64670

Product Name

Recombinant Cynomolgus Monkey CD223/LAG3 Protein, Fc Tag

Alias

Lymphocyte activation gene 3 protein, LAG3

Alternate Names

cd223,lag3,lag3 inhibitor,lag3 immune checkpoint,lag3 gene,lag3 protein,lag3 t cells,lag3 ligand,lag-3 ligand,lag-3 gene,Recombinant Protein,Cynomolgus Monkey CD223 Protein,cd223 protein,fc tag,fc tag protein

Official Symbol

CD223/LAG3

Species

Cynomolgus Monkey

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64670 Recombinant Cynomolgus Monkey CD223 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Ala18-His449(Pro74

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

50mM Tris, 100mM Glycine, pH7.5

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Anderson, P. M., Gupta, S. K., Williams, T. J., Roberts, L. M., Immunology, 2019, DOI: 10.1111/imm.13147, 

2 Taylor, A. R., Hernandez, J. R., Olson, K. M., Park, S. J., Cardiovascular Research, 2021, DOI: 10.1093/cvr/cvaa368

3 Smith, J. A., Brown, T. R., Clarke, S. H., Anderson, P. M., Journal of Cellular Biochemistry, 2018, DOI: 10.1002/jcb.27088

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