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Recombinant Cynomolgus Monkey CD279/PD-1 Protein, His Tag

Protein

Recombinant Cynomolgus Monkey CD279/PD-1 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Cynomolgus Monkey
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD279

PDCD1 (Programmed Cell Death 1) is a Protein Coding gene. Diseases associated with PDCD1 include Systemic Lupus Erythematosus 2 and Multiple Sclerosis. Among its related pathways are Infectious disease and SARS-CoV-2 Infection. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity.Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self.Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2.Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity).

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

Product Specification

Catalog Number

ALP64616

Product Name

Recombinant Cynomolgus Monkey CD279/PD-1 Protein, His Tag

Alias

Programmed cell death protein 1

Alternate Names

cd279 gene,cd279 protein,pd-1 inhibitor,pd-1 gene,pd-1 protein,recombinant pd-1,recombinant pd-1 protein,pd-1,pd-1 ligands,pd-1 checkpoint inhibitor,Recombinant Protein,Cynomolgus Monkey CD279 Protein,his tag,his tag protein

Official Symbol

CD279/PD-1

Species

Cynomolgus Monkey

Expression Host

HEK293 Cells

Protein Family

CTLA-4 Family

Product Description

ALP64616 Recombinant Cynomolgus Monkey CD279 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Pro21-Gln167 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Topalian, S. L., et al., The New England Journal of Medicine, 2012, DOI: 10.1056/NEJMoa1200690

2 Zou, W., and Chen, L., Nature Reviews Immunology, 2008, DOI: 10.1038/nri2326

3 Fife, B. T., and Bluestone, J. A., Immunological Reviews, 2008, DOI: 10.1111/j.1600-065X.2008.00654.x

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