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Recombinant Cynomolgus Monkey TNFSF18/GITRL Protein, His Tag

Protein

Recombinant Cynomolgus Monkey TNFSF18/GITRL Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Cynomolgus Monkey
  • Size: 50ug,100ug,500ug
  • Official Symbol: TNFSF18

TNFSF18 (TNF Superfamily Member 18) is a Protein Coding gene. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding.Cytokine that binds to TNFRSF18/AITR/GITR.Regulates T-cell responses.Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.

Product Specification

Catalog Number

ALP64536

Product Name

Recombinant Cynomolgus Monkey TNFSF18/GITRL Protein, His Tag

Alias

Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor ligand superfamily member 18, TNFSF18

Alternate Names

gitrl,tnfsf18,tnfsf18 elisa,gitrl protein,tnfsf18 protein,Cynomolgus Monkey TNFSF18 Protein,his tag,his tag protein,Recombinant Protein

Official Symbol

TNFSF18/GITRL

Species

Cynomolgus Monkey

Expression Host

HEK293 Cells

Protein Family

TNF Receptor Superfamily

Product Description

ALP64536 Recombinant Cynomolgus Monkey TNFSF18 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Glu74-Ser199 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Xie, J., et al., Nature Reviews Immunology, 2020, DOI: 10.1038/s41577-020-0367-x

2 Liu, H., & Zhang, J., Clinical Cancer Research, 2022, DOI: 10.1158/1078-0432.CCR-21-2389

3 Matsushima, K., et al., Matsushima, K., et al., 2005, DOI: 10.4049/jimmunol.174.8.4803

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