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Recombinant Cynomolgus Monkey VSTM3/TIGIT/VSIG9 Protein, His Tag

Protein

Recombinant Cynomolgus Monkey VSTM3/TIGIT/VSIG9 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Cynomolgus Monkey
  • Size: 50ug,100ug,500ug
  • Official Symbol: VSTM3

TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains) is a Protein Coding gene. Diseases associated with TIGIT include Endocervical Carcinoma and Chromophobe Renal Cell Carcinoma. Among its related pathways are Interactions of natural killer cells in pancreatic cancer and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is CD226.Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.  

 

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Product Background

T cell immunoreceptor with Ig and ITIM domains(TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif(ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells(DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113(PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.

Product Specification

Catalog Number

ALP64692

Product Name

Recombinant Cynomolgus Monkey VSTM3/TIGIT/VSIG9 Protein, His Tag

Alias

T-cell immunoreceptor with Ig and ITIM domains,, VSIG9

Alternate Names

tigit,tigit ligand,tigit receptor,tigit inhibitor,tigit protein,tigit gene,VSTM3 protein,VSIG9 protein,Recombinant Protein,Cynomolgus Monkey VSTM3 Protein,his tag,his tag protein

Official Symbol

VSTM3/TIGIT/VSIG9

Species

Cynomolgus Monkey

Expression Host

HEK293 Cells

Protein Family

CD28 Family

Product Description

ALP64692 Recombinant Cynomolgus Monkey VSTM3 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Met89-Pro209 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Joller, N., Hafler, J. P., Brynedal, B., Kassam, N., Spoerl, S., Levin, S. D., ... & Kuchroo, V. K., Journal of Immunology, 2011, DOI: 10.4049/jimmunol.1100139

2 Li, M., Xia, P., Du, Y., Liu, T., Wang, J., Zhang, W., ... & Tian, Z., Journal of Clinical Investigation, 2014, DOI: 10.1172/JCI80301

3 Lozano, E., Dominguez-Villar, M., Kuchroo, V., & Hafler, D. A., Journal of Immunology, 2012, DOI: 10.4049/jimmunol.1103627

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