English
Leave Your Message
Recombinant Human ANGPTL4/Angiopoietin-like protein 4  Protein, His Tag

Products

Recombinant Human ANGPTL4/Angiopoietin-like protein 4 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: ANGPTL4

ANGPTL4 (Angiopoietin Like 4) is a Protein Coding gene. Diseases associated with ANGPTL4 include Plasma Triglyceride Level Quantitative Trait Locus and Familial Hyperlipidemia. Among its related pathways are Cell junction organization and Regulation of CDH11 Expression and Function. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity. An important paralog of this gene is ANGPTL3. Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable).Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

Products Categories
Featured Products
recommended service
quick links
Contact Us

Product Background

Angiopoietin-related protein 4(ANGPTL4)is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity(By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix(ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Product Specification

Catalog Number

ALP64538

Product Name

Recombinant Human ANGPTL4/Angiopoietin-like protein 4  Protein, His Tag

Alias

Angiopoietin-related protein 4, 425O18-1, Angiopoietin-like protein 4, ANGPTL4

Alternate Names

angptl4,angptl4 gene,angptl4 elisa,human angptl4 elisa,human angptl4,recombinant angptl4,angptl4 protein,Angiopoietin-like protein 4,Recombinant Protein,his tag,his tag protein

Official Symbol

ANGPTL4/Angiopoietin-like protein 4

Species

Human

Expression Host

HEK293 Cells

Protein Family

Vascular Endolial Growth Factor Family

Product Description

ALP64538 Recombinant Human ANGPTL4 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Pro166-Ser406 is expressed with a 6His tag at the N-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

PPAR signaling pathway

Reference

1 Kersten, S., International Journal of Obesity, 2014, DOI: 10.1038/ijo.2014.70

2 Zhu, P., et al., The Journal of Clinical Investigation, 2011, DOI: 10.1172/JCI42039

3 Zhang, R., Open Biology, 2016, DOI: 10.1098/rsob.150272  1 Yang, Z., and Olivecrona, G., Trends in Endocrinology & Metabolism, 2016, DOI: 10.1016/j.tem.2015.10.003

FAQ

Leave Your Message