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Recombinant Human Biotinylated Mesothelin/MSLN Protein, His Tag, Avi Tag

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Recombinant Human Biotinylated Mesothelin/MSLN Protein, His Tag, Avi Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: Mesothelin

MSLN (Mesothelin) is a Protein Coding gene. Diseases associated with MSLN include Benign Mesothelioma and Malignant Pleural Mesothelioma. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. An important paralog of this gene is MSLNL.Membrane-anchored forms may play a role in cellular adhesion.Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa(pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Mesothelin plays an important role in cell survival, proliferation, migration, invasion, tumor progression, and resistance to chemotherapy. The overexpression of mesothelin can activate NF-κB and signal transducer and activator of transcription 3(Stat3), inhibit apoptotic signaling and TNF-α-induced apoptosis, and accelerate the G1–S transition. Mesothelin is also found overexpressed in various cancers, including malignant mesothelioma, pancreatic or ovarian carcinoma, sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues, mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy.

Product Specification

Catalog Number

ALP64544

Product Name

Recombinant Human Biotinylated Mesothelin/MSLN Protein, His Tag, Avi Tag

Alias

Megakaryocyte potentiating facto, Mesothelin

Alternate Names

mesothelin,mesothelin gene,msln gene,msln,msln elisa,human msln elisa,Human Mesothelin Protein,Recombinant Protein,his tag,his tag protein,avi tag,avi tag protein

Official Symbol

Mesothelin/MSLN

Species

Human

Expression Host

HEK293 Cells

Protein Family

Megakaryocyte Potentiating Factor Family

Product Description

ALP64544 Recombinant Human Biotinylated Mesothelin Protein, His Tag, Avi Tag is produced in HEK293 Cells and the target gene encoding Glu296-Ser598 is expressed with a 6His, Avi tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Hassan, R., & Ho, M., European Journal of Cancer, 2008, DOI: 10.1016/j.ejca.2008.04.024

2 Cheng, W. F., & Hung, C. F., Clinical Cancer Research, 2012, DOI: 10.1158/1078-0432.CCR-11-3211

3 Pastan, I., Hassan, R., Zhang, Y., Onda, M., & Bera, T., Clinical Cancer Research, 2004, DOI: 10.1158/1078-0432.CCR-1035-3

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