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Recombinant Human Biotinylated ROR1 Protein, His Tag, Avi Tag

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Recombinant Human Biotinylated ROR1 Protein, His Tag, Avi Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: ROR1

ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) is a Protein Coding gene. Diseases associated with ROR1 include Deafness, Autosomal Recessive 108 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are GPCR Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ROR2.Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo.Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling.In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

Receptor tyrosine kinase-like orphan receptor 1(ROR1), also known as neurotrophic tyrosine kinase, it is a member of the ROR family within receptor tyrosine kinases(RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids(aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain(ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. At developmental stage, it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Product Specification

Catalog Number

ALP64545

Product Name

Recombinant Human Biotinylated ROR1 Protein, His Tag, Avi Tag

Alias

Inactive tyrosine-protein kinase transmembrane receptor ROR1, ROR1

Alternate Names

ror1,ror1 expression,ror1 gene,ror1 inhibitor,Human ROR1 Protein,Recombinant Protein,his tag,his tag protein,avi tag,avi tag protein

Official Symbol

ROR1

Species

Human

Expression Host

HEK293 Cells

Protein Family

Kinase Superfamily

Product Description

ALP64545 Recombinant Human Biotinylated ROR1 Protein, His Tag, Avi Tag is produced in HEK293 Cells and the target gene encoding Gln30-Glu403 is expressed with a 6His, Avi tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Baskar, S., Kwong, K. Y., Chultes, B., Yao, C. Y., Chen, L., & Callahan, C., Clinical Cancer Research, 2008, DOI: 10.1158/1078-0432.CCR-07-1437

2 Zhang, L., Yeger, H., & Das, S., Cancer Letters, 2014, DOI: 10.1016/j.canlet.2014.08.010

3 Yu, J., Chen, L., Cui, B., Widhopf, G. F., Shen, Z., Wu, R., ... & Kipps, T. J., Journal of Clinical Investigation, 2016, DOI: 10.1172/JCI82804

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