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Recombinant Human BTLA/CD272 Protein, Fc Tag

Protein

Recombinant Human BTLA/CD272 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: BTLA

BTLA (B And T Lymphocyte Associated) is a Protein Coding gene. Diseases associated with BTLA include Rheumatoid Arthritis and Arthritis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include signaling receptor activity.Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2.May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14.In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

B- and T-Lymphocyte Attenuator(BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type(immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors(TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor(receptor) superfamily, member 14(TNFRSF14), also known as herpes virus entry mediator(HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

Product Specification

Catalog Number

ALP64654

Product Name

Recombinant Human BTLA/CD272 Protein, Fc Tag

Alias

B- and T-Lymphocyte Attenuator, CD272

Alternate Names

btla,btla gene,btla immune checkpoint,btla agonist,CD272,Recombinant Protein,btla protein,cd272 protein,Human CD272 Protein,Human BTLA Protein,fc tag,fc tag protein

Official Symbol

CD272/BTLA

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64654 Recombinant Human CD272 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Lys31-Leu150 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Hurchla, M. A., Sedy, J. R., Gavrieli, M., Murphy, T. L., Murphy, K. M., Nature Immunology, 2007, DOI: 10.1038/ni1477

2 Ware, C. F., Sedy, J. R., Current Opinion in Immunology, 2011, DOI: 10.1016/j.coi.2010.12.002

3 Steinberg, M. W., Turovskaya, O., Shaikh, R. B., Kim, G., McCole, D. F., Pfeffer, K., Ware, C. F., Kronenberg, M., The Journal of Experimental Medicine, 2008, DOI: 10.1084/jem.20080189

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