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Recombinant Human CD137L/4-1BBL/TNFSF9 Protein, His Tag

Protein

Recombinant Human CD137L/4-1BBL/TNFSF9 Protein, His Tag

  • Expression Host: E. coli
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD137L

TNFSF9 (TNF Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFSF9 include Immunodeficiency 16 and Mouth Disease. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding.Cytokine that binds to TNFRSF9.Induces the proliferation of activated peripheral blood T-cells.May have a role in activation-induced cell death (AICD). 

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death(AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction.

Product Specification

Catalog Number

ALP64683

Product Name

Recombinant Human CD137L/4-1BBL/TNFSF9 Protein, His Tag

Alias

CD137L, TNFSF9

Alternate Names

cd137l,4-1bbl,4-1bbl gene,tnfsf9,4-1BB ligand,cd137l protein,4-1bbl protein,tnfsf9 protein,Recombinant Protein,his tag,his tag protein,Human CD137L Protein

Official Symbol

CD137L/4-1BBL/TNFSF9

Species

Human

Expression Host

E. coli

Protein Family

TNF Superfamily

Product Description

ALP64683 Recombinant Human CD137L Protein, His Tag is produced in E.coli and the target gene encoding Arg71-Glu254 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM TrisHCl, 150mM NaCl, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Cytokine-cytokine receptor interaction

Reference

1 Shao, Z., Schwarz, H., Journal of Immunology, 2011, DOI: 10.4049/jimmunol.1001521

2 Shaikh, R. B., Santee, S., Granger, S. W., Butrovich, K., Cheung, T., Kronenberg, M., Cheroutre, H., Ware, C. F., Journal of Experimental Medicine, 2001, DOI: 10.1084/jem.20010809

3 Choi, B. K., Lee, D. Y., Lee, D. G., Kim, Y. H., Kim, S. H., Oh, H. S., Lee, S. J., Kwon, B. S., Journal of Immunology, 2010, DOI: 10.4049/jimmunol.1001637

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