English
Leave Your Message
Recombinant Human CD152/CTLA-4 Protein, GST Tag

Protein

Recombinant Human CD152/CTLA-4 Protein, GST Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD152

CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) is a Protein Coding gene. Diseases associated with CTLA4 include Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation and Celiac Disease 3. Among its related pathways are Gene expression (Transcription) and CD28 co-stimulation. An important paralog of this gene is CD28.Inhibitory receptor acting as a major negative regulator of T-cell responses.The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. 

 

Scientists at Alpha Lifetech have expertise in protein engineering, and with extensive expertise in protein engineering, we provide optimized recombinant proteins that enhance stability and functionality.

Products Categories
Featured Products
recommended service
quick links
Contact Us

Product Background

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Product Specification

Catalog Number

ALP64596

Product Name

Recombinant Human CD152/CTLA-4 Protein, GST Tag

Alias

Cytotoxic T-lymphocyte protein 4, CD152

Alternate Names

cd152,ctla4 cd152,human cd152,ctla-4,ctla-4 inhibitors,ctla-4 inhibitor,ctla-4 receptor,ctla-4 gene,ctla-4 ligand,ctla-4 signaling pathway,ctla-4 expression,ctla-4 signaling,ctla-4 cancer,ctla-4 pathway,Recombinant Protein,cd152 protein,ctla-4 protein,Human CD152 Protein,gst tag,gst protein tag

Official Symbol

CD152/CTLA-4

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64596 Recombinant Human CD152 Protein, GST Tag is produced in HEK293 Cells and the target gene encoding Lys36-Asp161 is expressed with a GST tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

Reference

1 Krummel, M. F., and Allison, J. P., The Journal of Experimental Medicine, 1996, DOI: 10.1084/jem.183.6.2533

2 Chambers, C. A., et al.,Immunological Reviews, 1999, DOI: 10.1111/j.1600-065X.1999.tb01339.x

3 Walunas, T. L., et al., Immunity, 1994, DOI: 10.1016/1074-7613(94)90144-9

FAQ

Leave Your Message