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Recombinant Human CD155/PVR Protein, His Tag

Protein

Recombinant Human CD155/PVR Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD155

PVR (PVR Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with PVR include Poliomyelitis and Paralytic Poliomyelitis. Among its related pathways are Cell junction organization and Innate Immune System. Gene Ontology (GO) annotations related to this gene include signaling receptor activity and virus receptor activity. An important paralog of this gene is NECTIN2.Mediates NK cell adhesion and triggers NK cell effector functions.Binds two different NK cell receptors: CD96 and CD226.These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell.

 

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Product Background

Poliovirus Receptor(PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like(Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus(PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms(α, β, γ, and δ) with identical extracellular domains.

Product Specification

Catalog Number

ALP64663

Product Name

Recombinant Human CD155/PVR Protein, His Tag

Alias

Poliovirus Receptor, CD155

Alternate Names

cd155,tigit cd155,cd155 receptor,pvr cd155,cd155 gene,cd155 expression,pvr research,pvr gene,pvr tigit,recombinant pvr,human pvr,pvr protein,human pvr protein,Recombinant Protein,his tag,his tag protein,Human CD155 Protein

Official Symbol

CD155/PVR

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64663 Recombinant Human CD155 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Trp21-Asn343 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Masson, D., Jarry, A., Baury, B., Blanchardie, P., Laboisse, C. L., Lustenberger, P., Tréhoux, A., Lévêque, J., Denis, M. G., Lustenberger, P., Gut, 2001, DOI: 10.1136/gut.49.2.236

2 Moulin, V., Andris, F., Thielemans, K., Maliszewski, C., Urbain, J., Moser, M., European Journal of Immunology, 1996, DOI: 10.1002/eji.1830261105

3 Koike, S., Horie, H., Ise, I., Okitsu, A., Yoshida, M., Iizuka, N., Takeuchi, K., Nomoto, A., Immunogenetics, 1995, 10.1007/BF00172442

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