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Recombinant Human CD172a/SHPS-1/SIRPA Protein, His Tag, Avi Tag

Protein

Recombinant Human CD172a/SHPS-1/SIRPA Protein, His Tag, Avi Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD172a

SIRPA (Signal Regulatory Protein Alpha) is a Protein Coding gene. Diseases associated with SIRPA include Hyperglycemia and Glioblastoma. Among its related pathways are Innate Immune System and Cell junction organization. Gene Ontology (GO) annotations related to this gene include SH3 domain binding. An important paralog of this gene is SIRPB1.Immunoglobulin-like cell surface receptor for CD47.
Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane.
Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

Signal Regulatory Protein α(SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation

Product Specification

Catalog Number

ALP64521

Product Name

Recombinant Human CD172a/SHPS-1/SIRPA Protein, His Tag, Avi Tag

Alias

CD172a, SHPS-1,SIRPA

Alternate Names

cd223,lag3,lag3 inhibitor,lag3 immune checkpoint,lag3 gene,lag3 protein,lag3 t cells,lag3 ligand lag-3 ligand,lag-3 gene,Recombinant Protein,Macaca Fascicularis CD223 Protein,cd223 protein,his tag,his tag protein

Official Symbol

CD172a/SHPS-1/SIRPA

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64521 Recombinant Human CD172a Protein, His Tag, Avi Tag is produced in HEK293 Cells and the target gene encoding Glu31-Arg370 is expressed with a 6His, Avi tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.2

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Barclay, A. N., Van den Berg, T. K., Annual Review of Immunology, 2014, DOI: 10.1146/annurev-immunol-032713-120142

2 Oldenborg, P. A., Zheleznyak, A., Fang, Y. F., Lagenaur, C. F., Gresham, H. D., Lindberg, F. P., Science, 2000, DOI: 10.1126/science.289.5480.1532

3 Alvey, C. M., Discher, D. E., Current Opinion in Immunology, 2017, DOI: 10.1016/j.coi.2017.07.007

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