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Recombinant Human CD223/LAG3 Protein, His Tag, Avi Tag

Protein

Recombinant Human CD223/LAG3 Protein, His Tag, Avi Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD223

LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. Diseases associated with LAG3 include Kyphoscoliotic Heart Disease and Endocervical Carcinoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and MHC class II protein binding. An important paralog of this gene is IL1RAPL1.Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells.Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity).FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity).

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]

Product Specification

Catalog Number

ALP64517

Product Name

Recombinant Human CD223/LAG3 Protein, His Tag, Avi Tag

Alias

Lymphocyte activation gene 3 protein, LAG3

Alternate Names

cd223,lag3,lag3 inhibitor,lag3 immune ,checkpoint,lag3 gene,lag3 protein,lag3 t cells,lag3 ligand,lag-3 ligand,lag-3 gene,Recombinant Protein,Human CD223 Protein,cd223 protein,his tag,his tag protein,avi tag,avi tag protein

Official Symbol

CD223/LAG3

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64517 Recombinant Human CD223 Protein, His Tag, Avi Tag is produced in HEK293 Cells and the target gene encoding Leu23-Leu450 is expressed with a 6His, Avi tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Smith, J. A., Brown, T. R., Clarke, S. H., Anderson, P. M., Journal of Cellular Biochemistry, 2018, DOI: 10.1002/jcb.27088

2 Johnson, L. M., Thompson, R. P., Green, E. J., West, D. M., Cancer Research, 2020, DOI: 10.1158/0008-5472.CAN-19-3014, 

3 Martinez, F. J., Lopez, R. A., Gomez, P. N., Silva, H. K., Neuroscience Letters, 2017, DOI: 10.1016/j.neulet.2017.08.014

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