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Recombinant Human CD226/DNAM-1 Protein, His Tag

Protein

Recombinant Human CD226/DNAM-1 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD226

CD226 (CD226 Molecule) is a Protein Coding gene. Diseases associated with CD226 include Mature Teratoma Of The Ovary and Ovarian Cystic Teratoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cell adhesion molecule binding. An important paralog of this gene is NECTIN3.Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.Cell surface receptor for NECTIN2.Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. 

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

Human DNAX accessory molecule 1(DNAM-1/CD226) is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. Mature human DNAM-1 contains an extracellular domain(ECD) with two Ig-like C2-set domains and a cytoplasmic region that contains motifs for binding PDZ domains and band 4.1 family proteins. DNAM-1 is expressed on multiple lymphoid and myeloid cells and interacts with CD155 and CD112. Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells, dendritic cell maturation, megakaryocyte and activated platelet adhesion to vascular endothelial cells, and monocyte extravasation; it inhibits the forrmation of osteoclasts. Plateletendothelium, interactions mediated by DNAM-1, enable the metastasis of tumor cells to the lung.

Product Specification

Catalog Number

ALP64578

Product Name

Recombinant Human CD226/DNAM-1 Protein, His Tag

Alias

CD226 antigen, CD226

Alternate Names

cd226,cd226 gene,cd226 protein,human cd226,dnam-1,Recombinant Protein,Human CD226 Protein,his tag,his tag protein

Official Symbol

CD226/DNAM-1

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64578 Recombinant Human CD226 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Glu19-Asn247 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Cell adhesion molecules (CAMs)

Reference

1 Shibuya, K., Lanier, L. L., Phillips, J. H., Ochs, H. D., Shimizu, K., Nakayama, E., Nakauchi, H., Shibuya, A., Immunity, 1999, DOI: 10.1016/S1074-7613(00)80526-1

2 Fuchs, A., Colonna, M., Seminars in Cancer Biology, 2006, DOI: 10.1016/j.semcancer.2006.10.006

3 Smyth, M. J., Hayakawa, Y., Takeda, K., Yagita, H., Nature Reviews Cancer, 2002, DOI: 10.1038/nrc821

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