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Recombinant Human CD244/2B4/SLAMF4 Protein, His Tag

Protein

Recombinant Human CD244/2B4/SLAMF4 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD244

CD244 (CD244 Molecule) is a Protein Coding gene. Diseases associated with CD244 include Tuberculosis and Rheumatoid Arthritis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Lymphoid Cells Differentiation. Gene Ontology (GO) annotations related to this gene include signaling receptor activity. An important paralog of this gene is SLAMF7.Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48.SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

Natural killer cell receptor 2B4 is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family.2B4 interacts with CD48, while other SLAM family proteins interact homophilically. Three additional splice variants of human 2B4 have deletions of the short region between the Ig-like domains, the second Ig-like domain, or a portion of the cytoplasmic tail.2B4 is expressed on all NK cells, γδ T cells, monocytes, some CD4+ and CD8+ T cells, and some dendritic cells. CD48 mediates 2B4+ cell interactions with nearly all hematopoietic cell types, including cells of the same type. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can either directly trigger inhibitory signaling or disrupt an inhibitory interaction, leading to cellular activation. The inhibitory effect is associated with the long form of 2B4, while the activation is associated with the short form. 2B4 can also induce signaling through CD48.

Product Specification

Catalog Number

ALP64579

Product Name

Recombinant Human CD244/2B4/SLAMF4 Protein, His Tag

Alias

Natural killer cell receptor 2B4, CD244

Alternate Names

cd244,cd244 gene,cd244 elisa,human cd244 elisa,human 2b4 elisa,2b4,2b4 gene,CD244 protein,2b4 protein,Recombinant Protein,Human CD244 Protein,his tag,his tag protein

Official Symbol

CD244/2B4/SLAMF4

Species

Human

Expression Host

HEK293 Cells

Protein Family

SLAM Family

Product Description

ALP64579 Recombinant Human CD244 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Cys22-Arg221 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Waggoner, S. N., Kumar, V., Frontiers in Immunology, 2012, DOI: 10.3389/fimmu.2012.00377

2 McNerney, M. E., Lee, K. M., Kumar, V., Journal of Immunology, 2005, DOI: 10.4049/jimmunol.175.7.4211

3 Chen, B. J., Cai, Q., Zhao, Q., Gu, J., Reese, J. S., Field, E. H., Liu, C., Journal of Clinical Investigation, 2008, DOI: 10.1172/JCI35062

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