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Recombinant Human CD258/LIGHT/TNFSF14 Protein, His Tag

Protein

Recombinant Human CD258/LIGHT/TNFSF14 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD258

TNFSF14 (TNF Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFSF14 include Rheumatoid Arthritis and Inflammatory Bowel Disease. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF15.Cytokine that binds to TNFRSF3/LTBR.Binding to the decoy receptor TNFRSF6B modulates its effects.Acts as a ligand for TNFRSF14/HVEM. 

 

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Product Background

Human TNFSF14 Protein, also known as LIGHT, belongs to a member of the tumor necrosis factor(TNF) ligand family. It can bind to NFRSF3/LTBR. It is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and it is also known as a herpesvirus entry mediator ligand(HVEML). TNFSF14 encodes a protein with a 37 aa cytoplasmic domain, 21aa transmembrane domain and 182 aa extracellular region. The gene is predominantly expressed in the spleen and also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines. TNFSF14 protein was found to probably function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Studies have shown that this protein can prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.

Product Specification

Catalog Number

ALP64617

Product Name

Recombinant Human CD258/LIGHT/TNFSF14 Protein, His Tag

Alias

Tumor necrosis factor ligand superfamily member 14, CD258

Alternate Names

cd258,cd258 protein,recombinant cd258,light protein,light gene,protein light,human light,tnfsf14 light,tnfsf14,human tnfsf14 elisa,light tnfsf14,recombinant human tnfsf14,Recombinant Protein,Human CD258 Protein,his tag,his tag protein

Official Symbol

CD258/LIGHT/TNFSF14

Species

Human

Expression Host

HEK293 Cells

Protein Family

TNF Superfamily

Product Description

ALP64617 Recombinant Human CD258 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Leu83-Val240 is expressed with a 6His tag at the N-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Maurer, U., Charvet, C., Wagman, A. S., Dejardin, E., Green, D. R., Blood, 2006, DOI: 10.1182/blood-2005-06-2379

2 Steinberg, M. W., Cheung, T. C., Ware, C. F., Immunological Reviews, 2011, DOI: 10.1111/j.1600-065X.2010.00995.x

3 Montgomery, R. I., Warner, M. S., Lum, B. J., Spear, P. G., Science, 1996, DOI: 10.1126/science.271.5246.868

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