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Recombinant Human CD27/TNFRSF7 Protein, Fc Tag, His Tag

Protein

Recombinant Human CD27/TNFRSF7 Protein, Fc Tag, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD27

CD27 (CD27 Molecule) is a Protein Coding gene. Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Combined Immunodeficiency. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is TNFRSF11A.Receptor for CD70/CD27L.May play a role in survival of activated T-cells.May play a role in apoptosis through association with SIVA1. 

 

Alpha Lifetech utilizes different expression systems to produce recombinant proteins in E. coli, yeast, insect, mammalian cells, and cell-free expression systems to meet different needs.

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Product Background

CD27 antigen is also known as CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, T14 and TNFRSF7. In humans, it is encoded by the CD27 gene. CD27 is a single-pass type I membrane protein with 3 TNFR-Cys repeats. It is a member of the TNF-receptor superfamily and is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. It plays a role in survival of activated T-cells and apoptosis through association with SIVA1.

Product Specification

Catalog Number

ALP64681

Product Name

Recombinant Human CD27/TNFRSF7 Protein, Fc Tag, His Tag

Alias

CD27 antigen, CD27L receptor, T-cell activation antigen CD27

Alternate Names

cd27,cd27 gene,cd27 flow cytometry,cd27 expression,cd27 elisa,human cd27,human cd27 protein,human cd27 elisa,cd27 marker,human tnfrsf7 elisa,Recombinant Protein,his tag,his tag protein

Official Symbol

CD27/TNFRSF7

Species

Human

Expression Host

HEK293 Cells

Protein Family

TNF-receptor Superfamily

Product Description

ALP64681 Recombinant Human CD27 Protein, Fc Tag, His Tag is produced in HEK293 Cells and the target gene encoding Thr21-Ile192 is expressed with a Fc, 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM Tris, 150mM NaCl, pH8.0

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Cytokine-cytokine receptor interaction

Reference

1 van de Ven, K., Borst, J., Seminars in Immunology, 1999, DOI: 10.1006/smim.1998.0138

2 Yang, Z., Aguilar, G. T., Swaminathan, S., Wang, L., Immunology and Cell Biology, 2010, DOI: 10.1038/icb.2010.28

3 Taraban, V. Y., Rowley, T. F., Al-Shamkhani, A., Trends in Molecular Medicine, 2004, DOI: 10.1016/j.molmed.2004.10.001

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