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Recombinant Human CD270/HVEM/TNFRSF14 Protein, Fc Tag

Protein

Recombinant Human CD270/HVEM/TNFRSF14 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD270

TNFRSF14 (TNF Receptor Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFRSF14 include Herpes Simplex and Herpetic Whitlow. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor receptor activity. An important paralog of this gene is TNFRSF11A.Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network.Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation.Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes.  

 

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Product Background

Herpesvirus entry mediator(HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on na-ve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte(IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

Product Specification

Catalog Number

ALP64660

Product Name

Recombinant Human CD270/HVEM/TNFRSF14 Protein, Fc Tag

Alias

Tumor Necrosis Factor Receptor Superfamily Member 14, CD270

Alternate Names

cd270,hvem gene,hvem,hvem protein,human hvem elisa,tnfrsf14,human tnfrsf14 elisa,tnfrsf14 elisa,cd279 protein,Recombinant Protein,Human CD270 Protein,fc tag,fc tag protein

Official Symbol

CD270/HVEM/TNFRSF14

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64660 Recombinant Human CD270 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Leu39-Val202 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Cytokine-cytokine receptor interaction

Reference

1 van Mierlo, G. J., & van Lier, R. A, Immunology and Cell Biology, 2011, DOI: 10.1038/icb.2011.3

2 Alderson, M. R., & Armitage, R. J., Immunity, 1996, DOI: 10.1016/S1074-7613(00)80236-1

3 Grumont, R. J., & Gerondakis, S., Journal of Immunology, 2001, DOI: 10.4049/jimmunol.166.11.6619

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