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Recombinant Human CD273/PD-L2/B7-DC Protein, His Tag

Protein

Recombinant Human CD273/PD-L2/B7-DC Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD273

PDCD1LG2 (Programmed Cell Death 1 Ligand 2) is a Protein Coding gene. Diseases associated with PDCD1LG2 include Cysticercosis and Autoimmune Cardiomyopathy. Among its related pathways are Phosphorylation of CD3 and TCR zeta chains and Innate Immune System. An important paralog of this gene is CD274.Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner.Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4. 

 

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Product Background

Programmed Cell Death 1 Ligand 2(PDCD1LG2) is a member of the BTN/MOG family. PDCD1LG2 contains one Ig-like C2-type domain and one Ig-like V-type domain. PDCD1LG2 is highly expressed in the heart, placenta, pancreas, lung and liver; it is weakly expressed in the spleen, lymph nodes, and thymus. PDCD1LG2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PDCD1LG2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Product Specification

Catalog Number

ALP64658

Product Name

Recombinant Human CD273/PD-L2/B7-DC Protein, His Tag

Alias

Programmed Cell Death 1 Ligand 2, CD273

Alternate Names

cd273,pd-l2,pd-l2 gene,pd-l2 expression,cd273 protein,pd-l2 protein,Recombinant Protein,Human CD273 Protein,his tag,his tag protein

Official Symbol

CD273/PD-L2/B7-DC

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64658 Recombinant Human CD273 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Leu20-Pro219 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.4

Storage

20mM PB, 150mM NaCl, pH7.4

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Cell adhesion molecules (CAMs)

Reference

1 Dong, H., & Chen, L., Journal of Immunology, 2002, DOI: 10.4049/jimmunol.169.7.3494

2 Lázár-Molnár, E., et al., Journal of Immunology, 2008, DOI: 10.4049/jimmunol.181.7.3797

3 Zhou, Q., et al., Clinical Cancer Research, 2009, DOI: 10.1158/1078-0432.CCR-09-0638

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