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Recombinant Human CD274/PD-L1/B7-H1 Protein, mFc Tag

Protein

Recombinant Human CD274/PD-L1/B7-H1 Protein, mFc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD274

CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include Composite Lymphoma and Trachea Carcinoma. Among its related pathways are Signaling by ALK and Phosphorylation of CD3 and TCR zeta chains. An important paralog of this gene is PDCD1LG2.Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response.Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). 

 

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Product Background

CD274, also known as B7-H1 or programmed death ligand 1(PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1(PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Product Specification

Catalog Number

ALP64690

Product Name

Recombinant Human CD274/PD-L1/B7-H1 Protein, mFc Tag

Alias

programmed cell death 1 ligand 1, CD274

Alternate Names

cd274 gene,pdl1 cd274,cd274,pd-l1 gene,pd-l1 protein,pd-l1 western blot,pd-l1 elisa,pd-l1,pd-l1 ihc,b7-h1,cd274 elisa,human cd274,human cd274 elisa,recombinant cd274,human cd274 protein,human pd-l1 elisa,pd-l1 immunohistochemistry,pd-l1 glycosylation,pd-l1 receptor,pd-l1 assays,human b7-h1 elisa,b7-h1 protein,Recombinant Protein

Official Symbol

CD274/PD-L1/B7-H1

Species

Human

Expression Host

HEK293 Cells

Protein Family

B7 family

Product Description

ALP64690 Recombinant Human CD274 Protein, mFc Tag is produced in HEK293 Cells and the target gene encoding Phe19-Thr239 is expressed with a mFc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Cell adhesion molecules (CAMs)

Reference

1 Taube, J. M., Klein, A., Brahmer, J. R., Xu, H., Pan, X., Kim, J. H., ... & Pardoll, D. M., Clinical Cancer Research, 2014, DOI: 10.1158/1078-0432.CCR-13-3271

2 Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., ... & Pardoll, D. M., New England Journal of Medicine, 2012, DOI: 10.1056/NEJMoa1200690

3 Pardoll, D. M., Nature Reviews Cancer, 2012, DOI: 10.1038/nrc3239

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