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Recombinant Human CD275/B7-H2/ICOSL Protein, His Tag

Protein

Recombinant Human CD275/B7-H2/ICOSL Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD275

ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Combined Immunodeficiency and Combined T And B Cell Immunodeficiency. Among its related pathways are CD28 Signaling in T-Helper Cell and Immune response NFAT in immune response. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is CD276.Ligand for the T-cell-specific cell surface receptor ICOS.Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). 

 

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Product Background

Inducible Co-Stimulator Ligand(ICOSLG) belongs to the immunoglobulin superfamily. ICOSLG contains Ig-like C2-type(immunoglobulin-like) domain and 1 Ig-like V-type(immunoglobulin-like) domain. ICOSLG acts as a costimulatory signal for T-cell proliferation and cytokine secretion, it also induces B-cell proliferation and differentiation into plasma cells. It could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. ICOSLG is widely expressed lymph nodes, leukocytes and spleen, detected on activated monocytes and dendritic cells.

Product Specification

Catalog Number

ALP64664

Product Name

Recombinant Human CD275/B7-H2/ICOSL Protein, His Tag

Alias

B7 homolog 2, B7-H2

Alternate Names

cd275,b7-h2,icosl,icosl gene,icosl protein,CD275 protein,b7-h2 protein,Recombinant Protein,Human CD275 Protein,his tag,his tag protein

Official Symbol

CD275/B7-H2/ICOSL

Species

Human

Expression Host

HEK293 Cells

Protein Family

B7 family

Product Description

ALP64664 Recombinant Human CD275 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Asp19-Ser258 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, 1mM EDTA, pH7.2

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Cell adhesion molecules (CAMs)

Reference

1 Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A., Nature, 1999, DOI: 10.1038/74047

2 Coyle, A. J., Lehar, S., Lloyd, C., Tian, J., Delaney, T., Manning, S., ... & Gutierrez-Ramos, J. C., Immunity, 2000, DOI: 10.1016/S1074-7613(00)80027-9

3 Wang, S., Zhu, G., Chapoval, A. I., Dong, H., Tamada, K., Ni, J., & Chen, L., Blood, 2000, DOI: 10.1182/blood.V96.8.2808

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