Protein
- +1 609-736-0910
- [email protected]
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ALP64680 |
Product Name |
Recombinant Human CD278/ICOS Protein, Fc Tag |
Alias |
Inducible T-cell costimulator, CD278 |
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Alternate Names cd278,icos gene,icos protein,icos ligand,icos expression,icos receptor,human icos,human icos protein,Recombinant Protein,Human CD278 Protein,fc tag,fc tag protein |
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Official Symbol CD278/ICOS |
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Species |
Human |
Expression Host |
HEK293 Cells |
Protein Family |
CTLA4 Family |
Product Description |
ALP64680 Recombinant Human CD278 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Glu21-Phe141 is expressed with a Fc tag at the C-terminus. |
Size |
50ug,100ug,500ug |
Purification |
Affinity Purification |
Purity |
>90%-95% as determined by SDS-PAGE |
Endotoxin |
<1.0 EU/ug determined by the LAL method |
Buffer |
Supplied in PBS, pH7.4 |
Storage |
For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles. |
Shipping Condition |
Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice. |
Note |
This product is for research use only. This product can not be used for human. |
Protein Pathways |
Cell adhesion molecules (CAMs), Primary immunodeficiency, T cell receptor signaling pathway |
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Reference 1 Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999). ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature, 397(6716), 263-266. DOI: 10.1038/16717 2 Coyle, A. J., & Gutierrez-Ramos, J. C. (2001). The role of ICOS and other costimulatory molecules in allergy and asthma. Springer Seminars in Immunopathology, 23(3), 245-255. DOI: 10.1007/s002810100083 3 Simpson, T. R., Quezada, S. A., & Allison, J. P. (2010). Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS). Current Opinion in Immunology, 22(3), 326-332. DOI: 10.1016/j.coi.2010.02.007 |
FAQ
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What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
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How can I obtain COA of the reagent that I received?
Please contact us via email [email protected] for detailed information about the product.
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Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
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How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email [email protected] for more detailed information.