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Recombinant Human CD326/EpCAM Protein, His Tag, Avi Tag

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Recombinant Human CD326/EpCAM Protein, His Tag, Avi Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD326

EPCAM (Epithelial Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with EPCAM include Diarrhea 5, With Tufting Enteropathy, Congenital and Lynch Syndrome 8. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include protein-containing complex binding. An important paralog of this gene is TACSTD2.May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection.Plays a role in embryonic stem cells proliferation and differentiation.Up-regulates the expression of FABP5, MYC and cyclins A and E. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

Epithelial Cell Adhesion Molecule(EpCAM) is a signal type I transmembrane glycoprotein that belongs to the EPCAM family. EpCAM is composed of an extracellular domain with one thyroglobulin type-1 domain, a transmembrane domain and a cytoplasmic domain. EpCAM is found on the surface of adenocarcinoma, but not on mesodermal or neural cell membranes. The EpCAM molecule has been shown to function as a homophilic Ca2+ independent adhesion molecule. It may act as a physical homophilic interaction molecule between intestinal epithelial cells(IECs) and intraepithelial lymphocytes(IELs) at the mucosal epithelium as an immunological barrier providing the first line of defense against infection. Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8(HNPCC8) and diarrhea type 5(DIAR5). EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells.

Product Specification

Catalog Number

ALP64542

Product Name

Recombinant Human CD326/EpCAM Protein, His Tag, Avi Tag

Alias

Epithelial Cell Adhesion Molecule, CD326

Alternate Names

cd326,cd326 protein,epcam,epcam gene,epcam protein,epcam expression,human epcam protein,recombinant epcam,human epcam elisa,human epcam,Human CD326 Protein,Recombinant Protein,his tag,his tag protein,avi tag,avi tag protein

Official Symbol

CD326/EpCAM

Species

Human

Expression Host

HEK293 Cells

Protein Family

CAM Family

Product Description

ALP64542 Recombinant Human CD326 Protein, His Tag, Avi Tag is produced in HEK293 Cells and the target gene encoding Gln24-Lys265 is expressed with a 6His, Avi tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.2

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Yarden, Y., and Sliwkowski, M. X.,  Annual Review of Biochemistry, 2001, DOI: 10.1146/annurev.biochem.70.1.343

2 Arteaga, C. L., Cancer and Metastasis Reviews, 2003, DOI: 10.1023/A:1026241713629

3 Herbst, R. S., European Journal of Cancer Supplements, 2004, DOI: 10.1016/j.ejcsup.2004.06.007

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