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Recombinant Human CD33L3/Siglec-15 Protein, His Tag

Protein

Recombinant Human CD33L3/Siglec-15 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD33L3

SIGLEC15 (Sialic Acid Binding Ig Like Lectin 15) is a Protein Coding gene. Diseases associated with SIGLEC15 include Chromophobe Renal Cell Carcinoma and Endocervical Carcinoma. Among its related pathways are Innate Immune System and DAP12 interactions. An important paralog of this gene is SIGLEC5.Binds sialylated glycoproteins.

 

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Product Background

Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO--terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain(Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid(aa) extracellular domain(ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts

Product Specification

Catalog Number

ALP64631

Product Name

Recombinant Human CD33L3/Siglec-15 Protein, His Tag

Alias

Sialic acid-binding Ig-like lectin 15, Siglec-15

Alternate Names

siglec-15,CD33L3,Human CD33L3 Protein,siglec-15 protein,CD33L3 protein,Recombinant Protein,his tag,his tag protein

Official Symbol

CD33L3/Siglec-15

Species

Human

Expression Host

HEK293 Cells

Protein Family

Siglec Family

Product Description

ALP64631 Recombinant Human CD33L3 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Phe20-Thr263 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

PBS, 150mM Nacl, 0.3% Chaps, 5% Trehalose, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Baskin, D. G., et al., Immunology Letters, 2021, DOI: 10.1016/j.imlet.2020.09.005

2 Koh, S., et al., Current Opinion in Immunology, 2022, DOI: 10.1016/j.coi.2022.03.007

3 Reeves, R., et al., Nature Reviews Immunology, 2023, DOI: 10.1038/s41577-022-00776-5

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