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Recombinant Human CD357/GITR/TNFRSF18 Protein, Fc Tag

Protein

Recombinant Human CD357/GITR/TNFRSF18 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD357

TNFRSF18 (TNF Receptor Superfamily Member 18) is a Protein Coding gene. Diseases associated with TNFRSF18 include Diverticulitis and Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked. Among its related pathways are Gene expression (Transcription) and Akt Signaling. Gene Ontology (GO) annotations related to this gene include tumor necrosis factor receptor activity. An important paralog of this gene is TNFRSF8.Receptor for TNFSF18.Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.Mediated NF-kappa-B activation via the TRAF2/NIK pathway. 

 

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Product Background

Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Product Specification

Catalog Number

ALP64694

Product Name

Recombinant Human CD357/GITR/TNFRSF18 Protein, Fc Tag

Alias

Tumor necrosis factor receptor superfamily member 18, CD357

Alternate Names

cd357,gitr,gitr protein,gitr gene,gitr ligand,gitr agonist,human gitr elisa,gitr ligand protein,human gitr,human gitr ligand,tnfrsf18,tnfrsf18 gene,tnfrsf18 protein,tnfrsf18 elisa,human tnfrsf18 elisa,Recombinant Protein,fc tag,fc tag protein

Official Symbol

CD357/GITR/TNFRSF18

Species

Human

Expression Host

HEK293 Cells

Protein Family

TNF Receptor Superfamily

Product Description

ALP64694 Recombinant Human CD357 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Gln26-Gln161 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Cytokine-cytokine receptor interaction

Reference

1 Huang, L. et al. (2017). "The role of programmed cell death-1 in immune regulation and tumor immune evasion." Frontiers in Immunology, 8, 1531. doi:10.3389/fimmu.2017.01531.

2 Thommen, D. S. et al. (2018). "Progressive loss of T-cell receptor signaling in the tumor microenvironment." Nature, 544(7649), 111-115. doi:10.1038/nature21795.

3 Nishimura, H. et al. (1999). "Role of PD-1 in the regulation of immune responses." Immunity, 11(2), 141-151. doi:10.1016/S1074-7613(00)00134-3.Combination Therapies:

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