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Recombinant Human CD3E/CD3 Epsilon Protein, mFc Tag

Protein

Recombinant Human CD3E/CD3 Epsilon Protein, mFc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD3E

CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are Immune response NFAT in immune response and TCR Signaling (Qiagen). Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and obsolete signal transducer activity. An important paralog of this gene is CD3G.Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

T-Cell Surface Glycoprotein CD3 ε Chain(CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like(immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex(TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs(ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

Product Specification

Catalog Number

ALP64519

Product Name

Recombinant Human CD3E/CD3 Epsilon Protein, mFc Tag

Alias

T-Cell Surface Glycoprotein CD3 Epsilon Chain, CD3E

Alternate Names

cd3e,cd3e marker,cd3e gene,cd3e protein,cd3 epsilon,Human CD3E Protein,Recombinant Protein

Official Symbol

CD3E/CD3 Epsilon

Species

Human

Expression Host

HEK293 Cells

Product Description

ALP64519 Recombinant Human CD3E Protein, mFc Tag is produced in HEK293 Cells and the target gene encoding Gln22-Thr48 is expressed with a mFc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

Reference

1 Zhang, W., et al., Immunological Reviews, 1998, DOI: 10.1111/j.1600-065X.1998.tb01293.x

2 Alam, S. M., et al., Advances in Immunology, 2001, DOI: 10.1016/S0065-2776(01)47001-7

3 Qiu, J., et al., Oncoimmunology, 2015, DOI: 10.1080/2162402X.2015.1083933

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