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Recombinant Human CD47/MER6 Protein, Fc Tag, Avi Tag

Protein

Recombinant Human CD47/MER6 Protein, Fc Tag, Avi Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD47

CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Hemolytic Anemia. Among its related pathways are Innate Immune System and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity.Adhesive protein that mediates cell-to-cell interactions.Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins.Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation.

 

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Product Background

CD47(Integrin-Associated Protein,IAP) is a 40 - 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.

Product Specification

Catalog Number

ALP64575

Product Name

Recombinant Human CD47/MER6 Protein, Fc Tag, Avi Tag

Alias

Leukocyte Surface Antigen CD47, MER6

Alternate Names

cd47,cd47 gene,cd47 inhibitor,cd47 protein,recombinant cd47,cd47 ligand,cd47 receptor,human cd47 protein,Recombinant Protein,fc tag,fc tag protein,avi tag,avi tag protein

Official Symbol

CD47/MER6

Species

Human

Expression Host

HEK293 Cells

Protein Family

SHPS/SIRP Family

Product Description

ALP64575 Recombinant Human CD47 Protein, Fc Tag, Avi Tag is produced in HEK293 Cells and the target gene encoding Gln19-Pro139 is expressed with a Fc, Avi tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Oldenborg, P. A., Leukemia & Lymphoma, 2004, DOI: 10.1080/1042819042000207554

2 Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P., Mitra, S. S., ... & Weissman, I. L., Proceedings of the National Academy of Sciences, 2012, DOI: 10.1073/pnas.1121623109

3 Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., ... & Weissman, I. L., Cell, 2009, DOI: 10.1016/j.cell.2009.06.045

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