English
Leave Your Message
Recombinant Human CD48/SLAMF2 Protein, Fc Tag, His Tag

Protein

Recombinant Human CD48/SLAMF2 Protein, Fc Tag, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD48

CD48 (CD48 Molecule) is a Protein Coding gene. Diseases associated with CD48 include Lymphoproliferative Syndrome, X-Linked, 1 and Macs Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Gastric cancer network 2. Gene Ontology (GO) annotations related to this gene include signaling receptor activity and antigen binding. An important paralog of this gene is SLAMF8.Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation.Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex.In turn, promotes LCK phosphorylation and subsequent activation. 

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

Products Categories
Featured Products
recommended service
quick links
Contact Us

Product Background

CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains one Ig-like C2-type domain and one Ig-like V-type domain, but does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. CD48 may facilitate interaction between activated lymphocytes and be involved in regulating T-cell activation. CD48 plays a vital role as an environmental sensor for regulating progenitor cell numbers and inhibiting tumor development. It is suggested that the anti-CD48 mAb has the potential to become an effective therapeutic mAb against multiple myeloma.

Product Specification

Catalog Number

ALP64656

Product Name

Recombinant Human CD48/SLAMF2 Protein, Fc Tag, His Tag

Alias

SLAM Family Member 2, CD48

Alternate Names

cd48,cd48 gene,cd48 marker,human cd48 elisa,cd48 elisa,Recombinant Protein,his tag,his tag protein,Human CD48 Protein,fc tag,fc tag protein

Official Symbol

CD48/SLAMF2

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64656 Recombinant Human CD48 Protein, Fc Tag, His Tag is produced in HEK293 Cells and the target gene encoding Gln27-Ser220 is expressed with a Fc, 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Bottino, C., Castriconi, R., Moretta, L., & Moretta, A. (2004). Cellular ligands of activating NK receptors. Trends in Immunology, 25(5), 285-291. DOI: 10.1016/j.it.2004.03.008

2 Liu, Y., & Eisenbarth, S. C. (2020). CD48: A co-stimulatory molecule regulating interactions between immune cells in inflammatory diseases, cancer, and infections. Frontiers in Immunology, 11, 614925. DOI: 10.3389/fimmu.2020.614925

3 Perez-Quintero, L. A., Roncagalli, R., Guo, H., Latour, S., & Davidson, D. (2014). EAT-2 and ERT molecules regulate activating receptor–dependent NK cell functions through phospholipase Cγ1. Journal of Immunology, 192(3), 875-884

FAQ

Leave Your Message