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Recombinant Human CD66a/CEACAM1 Protein, His Tag

Protein

Recombinant Human CD66a/CEACAM1 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD66a

CEACAM1 (CEA Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CEACAM1 include Adenomatoid Tumor and Colorectal Cancer. Among its related pathways are Innate Immune System and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CEACAM5.[Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity).Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis.Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors.

 

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Product Background

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1(CEACAM1) is a member of the Carcinoembryonic Antigen(CEA) family, which belongs to the immunoglobulin superfamily. CEACAM1 is originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it is found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. CEACAM1 mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. In addition, CEACAM1 plays a important role in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.

Product Specification

Catalog Number

ALP64665

Product Name

Recombinant Human CD66a/CEACAM1 Protein, His Tag

Alias

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1, CD66a

Alternate Names

ceacam1,ceacam1 gene,ceacam1 protein,human ceacam1,human ceacam1 elisa,ceacam1 elisa,cd66a,Human CD66a Protein,Recombinant Protein,his tag,his tag protein

Official Symbol

CD66a/CEACAM1

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64665 Recombinant Human CD66a Protein, His Tag is produced in HEK293 Cells and the target gene encoding Gln35-Gly428 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.2

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Gray-Owen, S. D., & Blumberg, R. S. (2006). CEACAM1: contact-dependent control of immunity. Nature Reviews Immunology, 6(6), 433-446. DOI: 10.1038/nri1852

2 Beauchemin, N., & Arabzadeh, A. (2013). Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Reviews, 32(3-4), 643-671. DOI: 10.1007/s10555-013-9444-6

3 Horst, A. K., Wagener, C., & Kuespert, K. (2011). The extracellular domain of CEACAM1: functional and structural insights from NMR and crystallography studies. Current Opinion in Structural Biology, 21(5), 658-665. DOI: 10.1016/j.sbi.2011.09.004

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