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Recombinant Human CD70/CD27L Protein, Fc Tag

Protein

Recombinant Human CD70/CD27L Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD70

CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Lymphoproliferative Syndrome 3 and Lymphoma. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protease binding.Cytokine which is the ligand for CD27.The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses.Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. 

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

CD27 Ligand(CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor(TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Product Specification

Catalog Number

ALP64647

Product Name

Recombinant Human CD70/CD27L Protein, Fc Tag

Alias

Tumor necrosis factor ligand superfamily member 7, CD70

Alternate Names

cd70,cd70 gene,cd70 expression,recombinant cd70,cd70 protein,human cd70 protein,human cd70,cd70 elisa,Recombinant Protein

Official Symbol

CD70/CD27L

Species

Human

Expression Host

HEK293 Cells

Protein Family

TNF Ligand Family

Product Description

ALP64647 Recombinant Human CD70 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Gln45-Pro193 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Cytokine-cytokine receptor interaction

Reference

1 Bennett, L. et al., Cancer Immunology, Immunotherapy, 2010, DOI: 10.1007/s00262-010-0831-5

2 Hughes, C. et al., Current Opinion in Immunology, 2018, DOI: 10.1016/j.coi.2018.10.003

3 Schnell, A. et al., European Journal of Immunology, 2017, DOI: 10.1002/eji.201646676

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