Protein
- +1 609-736-0910
- [email protected]
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ALP64608 |
Product Name |
Recombinant Human CD80/B7-1 Protein, His Tag |
Alias |
T-lymphocyte activation antigen CD80, Activation B7-1 antigen |
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Alternate Names cd80 marker,cd80 function,cd80 expression,cd80,cd80 gene,cd80 protein,human cd80,recombinant cd80,human cd80 protein,b7-1,recombinant b7-1,Recombinant Protein,his tag,his tag protein |
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Official Symbol CD80/B7-1 |
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Species |
Human |
Expression Host |
HEK293 Cells |
Protein Family |
Immunoglobulin Superfamily |
Product Description |
ALP64608 Recombinant Human CD80 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Val35-Asn242 is expressed with a 6His tag at the C-terminus. |
Size |
50ug,100ug,500ug |
Purification |
Affinity Purification |
Purity |
>90%-95% as determined by SDS-PAGE |
Endotoxin |
<1.0 EU/ug determined by the LAL method |
Buffer |
Supplied in PBS, pH7.4 |
Storage |
For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles. |
Shipping Condition |
Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice. |
Note |
This product is for research use only. This product can not be used for human. |
Protein Pathways |
Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis |
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Reference 1 Carreno, B. M., & Collins, M. (2002). The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annual Review of Immunology, 20(1), 29-53. DOI: 10.1146/annurev.immunol.20.091101.091806 2 Freeman, G. J., & Sharpe, A. H. (2012). A new therapeutic strategy for cancer: targeting the PD-1/PD-L1 pathway. Advances in Immunology, 114, 261-296. DOI: 10.1016/B978-0-12-396548-6.00006-4 3 Linsley, P. S., Brady, W., Grosmaire, L., Aruffo, A., Damle, N. K., & Ledbetter, J. A. (1991). Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. Journal of Experimental Medicine, 173(3), 721-730. DOI: 10.1084/jem.173.3.721 |
FAQ
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What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
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How can I obtain COA of the reagent that I received?
Please contact us via email [email protected] for detailed information about the product.
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Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
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How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email [email protected] for more detailed information.