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Recombinant Human CD86/B7-2 Protein, His Tag

Protein

Recombinant Human CD86/B7-2 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD86

CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Plague and Cowpox. Among its related pathways are CD28 co-stimulation and PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and coreceptor activity. An important paralog of this gene is CD80.Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4.May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation.Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. 

 

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Product Background

The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type(immunoglobulin-like) domain.

Product Specification

Catalog Number

ALP64627

Product Name

Recombinant Human CD86/B7-2 Protein, His Tag

Alias

T-lymphocyte activation antigen CD86, CD86

Alternate Names

cd86,cd86 marker,cd86 gene,cd86 protein,human cd86,b7-2,Human CD86 Protein,b7-2 protein,Recombinant Protein,his tag,his tag protein

Official Symbol

CD86/B7-2

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64627 Recombinant Human CD86 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Ala24-Pro247 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.2

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis

Reference

1 Bhatia, S., Edidin, M., Almo, S. C., & Nathenson, S. G., Immunity, 2005, DOI: 10.1016/j.immuni.2005.06.015

2 Fraser, J. D., & Germain, R. N., Immunity, 1993, DOI: 10.1016/1074-7613(93)90061-P

3 Coyle, A. J., & Gutierrez-Ramos, J. C., Immunological Reviews, 2001, DOI: 10.1034/j.1600-065X.2001.0910103.x

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