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Recombinant Human FGL1 Protein, Fc Tag

Protein

Recombinant Human FGL1 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: FGL1

FGL1 (Fibrinogen Like 1) is a Protein Coding gene. Diseases associated with FGL1 include Hepatocellular Carcinoma and Lung Cancer. An important paralog of this gene is ANGPTL2.Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3.Responsible for LAG3 T-cell inhibitory function.Binds LAG3 independently from MHC class II (MHC-II).

 

Alpha Lifetech utilizes different expression systems to produce recombinant proteins in E. coli, yeast, insect, mammalian cells, and cell-free expression systems to meet different needs.

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Product Background

Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3.

Product Specification

Catalog Number

ALP64528

Product Name

Recombinant Human FGL1 Protein, Fc Tag

Alias

Fibrinogen-like protein 1, FGL1

Alternate Names

fgl1,fgl1 lag3,fgl1 gene,fgl1 protein,Human FGL1 Protein,Recombinant Protein,Recombinant fgl1 Protein,fc tag,fc tag protein

Official Symbol

FGL1

Species

Human

Expression Host

HEK293 Cells

Protein Family

Fibronogen Superfamily

Product Description

ALP64528 Recombinant Human FGL1 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Leu23-Ile312 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, 5% Trehalose, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Guo, J., et al., Cancer Immunology Research, 2020, DOI: 10.1158/2326-6066.CIR-19-0383

2 Chia, C. S., et al., Journal of Immunology, 2011, DOI: 10.4049/jimmunol.11060

3 Xu, J., et al., Journal of Experimental & Clinical Cancer Research, 2021, DOI: 10.1186/s13046-021-02063-1

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