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Recombinant Human Gi24/B7-H5/VISTA Protein, Fc Tag

Protein

Recombinant Human Gi24/B7-H5/VISTA Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: Gi24

VSIR (V-Set Immunoregulatory Receptor) is a Protein Coding gene. Diseases associated with VSIR include Hard Palate Cancer and Ocular Cancer. Among its related pathways are NF-kappaB Signaling and T cell modulation in pancreatic cancer. An important paralog of this gene is IGSF11.Immunoregulatory receptor which inhibits the T-cell response.May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).May stimulate MMP14-mediated MMP2 activation. 

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling pathway. It also regulates the CD4-pasitive, alpha-beta T cell proliferation, and T cell cytokine production negatively. However, the protein can regulate stem cell differentiation positively.

Product Specification

Catalog Number

ALP64662

Product Name

Recombinant Human Gi24/B7-H5/VISTA Protein, Fc Tag

Alias

Platelet receptor Gi24, Gi24

Alternate Names

vista immune checkpoint,vista gene,vista target,vista protein,vista ligand,Gi24 protein,B7-H5 protein,Recombinant Protein,Human Gi24 Protein,fc tag,fc tag protein

Official Symbol

Gi24/B7-H5/VISTA

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64662 Recombinant Human Gi24 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Phe33-Ala194 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Lines, J. L., Pantazi, E., Mak, J., Sempere, L. F., Wang, L., O'Malley, Y., ... & Noelle, R., Cancer Research, 2014, DOI: 10.1158/0008-5472.CAN-14-0112

2 Wang, L., Rubinstein, R., Lines, J. L., Wasiuk, A., Ahonen, C., Guo, Y., ... & Noelle, R. J., Journal of Experimental Medicine, 2011, DOI: 10.1084/jem.20100619

3 Le Mercier, I., Lines, J. L., Noelle, R. J., & Wang, L., Frontiers in Immunology, 2015, DOI: 10.3389/fimmu.2015.00258

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