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Recombinant Human HAVCR2/TIM3/TIMD3 Protein, His Tag

Protein

Recombinant Human HAVCR2/TIM3/TIMD3 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: HAVCR2

HAVCR2 (Hepatitis A Virus Cellular Receptor 2) is a Protein Coding gene. Diseases associated with HAVCR2 include T-Cell Lymphoma, Subcutaneous Panniculitis-Like and Hepatitis A. Among its related pathways are Cytokine Signaling in Immune system and Interleukin-2 family signaling. An important paralog of this gene is HAVCR1.Cell surface receptor implicated in modulating innate and adaptive immune responses.Generally accepted to have an inhibiting function.Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand.

 

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Product Background

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. 

Product Specification

Catalog Number

ALP64674

Product Name

Recombinant Human HAVCR2/TIM3/TIMD3 Protein, His Tag

Alias

Hepatitis A virus cellular receptor 2, HAVCR2

Alternate Names

havcr2,havcr2 gene,tim3,tim3 receptor,anti-tim3,tim3 inhibitor,tim3 gene,tim3 checkpoint inhibitor,tim3 signaling,tim3 function,tim3 ligand,tim3 marker,Human HAVCR2 Protein,havcr2 protein,tim3 protein,human tim3,Recombinant Protein,his tag,his tag protein

Official Symbol

HAVCR2/TIM3/TIMD3

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64674 Recombinant Human HAVCR2 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Ser22-Arg200 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Wolf, Y., Anderson, A. C., & Kuchroo, V. K., Trends in Immunology, 2020, DOI: 10.1016/j.it.2020.02.007

2 Anderson, A. C., Joller, N., & Kuchroo, V. K., Immunity, 2016, DOI: 10.1016/j.immuni.2016.07.003

3 Zhu, C., Anderson, A. C., Schubart, A., Xiong, H., Imitola, J., Khoury, S. J., ... & Kuchroo, V. K., Nature Immunology, 2005, DOI: 10.1038/ni1167

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