English
Leave Your Message
Recombinant Human Tie-2 Protein, Fc Tag

Protein

Recombinant Human Tie-2 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: Tie-2

TEK (TEK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TEK include Venous Malformations, Multiple Cutaneous And Mucosal and Glaucoma 3, Primary Congenital, E. Among its related pathways are GPCR Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TIE1.Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence.Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels.Required for normal angiogenesis and heart development during embryogenesis. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

Products Categories
Featured Products
recommended service
quick links
Contact Us

Product Background

Tie-1/Tie(tyrosine kinase with Ig and EGF homology domains 1) and Tie-2/Tek comprise a receptor tyrosine kinase(RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor(EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human Tie-2 cDNA encodes a 1124 amino acid(aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1(Ang-1) and angiopoietin-2(Ang-2), which bind Tie-2 with high-affinity have been identified. Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

Product Specification

Catalog Number

ALP64518

Product Name

Recombinant Human Tie-2 Protein, Fc Tag

Alias

angiopoietin-1 receptor, CD202b

Alternate Names

tie-2,tie-2 gene,tie-2 inhibitor,Human Tie-2 Protein,Recombinant Protein,fc tag,fc tag protein

Official Symbol

Tie-2

Species

Human

Expression Host

HEK293 Cells

Protein Family

Tie Subfamily

Product Description

ALP64518 Recombinant Human Tie-2 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Ala23-Leu748 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Yancopoulos, G. D., et al., Nature, 2000, DOI: 10.1038/35001581

2 Saharinen, P., et al., Clinical and Experimental Pharmacology and Physiology, 2011, DOI: 10.1111/j.1440-1681.2010.05416.x

3 Bussolati, B., et al., Nature Reviews Cancer, 2010, DOI: 10.1038/nrc2923

FAQ

Leave Your Message