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Recombinant Human TNFRSF17/BCMA Protein, Fc Tag, Avi Tag

Protein

Recombinant Human TNFRSF17/BCMA Protein, Fc Tag, Avi Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: TNFRSF17

TNFRSF17 (TNF Receptor Superfamily Member 17) is a Protein Coding gene. Diseases associated with TNFRSF17 include Macroglobulinemia and Lymphoma. Among its related pathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation. Gene Ontology (GO) annotations related to this gene include signaling receptor activity. An important paralog of this gene is TNFRSF13C. Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.Promotes B-cell survival and plays a role in the regulation of humoral immunity.Activates NF-kappa-B and JNK.

 

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Product Background

B cell maturation protein(BCMA) is a type III membrane protein which belongs to the TNF receptor superfamily(TNFRSF17). BCMA contains one extracellular cysteine rich domain, as well as TACI. Human BCMA is a 184 amino acid(aa) protein consisting of a 54 aa extracellular domain, a 23 aa transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity. BCMA is mainly expressed in immune organs and mature B cell lines. BCMA appears to be localized to the Golgi compartment. BCMA may play an important role in B cell development, function and regulation.

Product Specification

Catalog Number

ALP64524

Product Name

Recombinant Human TNFRSF17/BCMA Protein, Fc Tag, Avi Tag

Alias

CD269, Bcma

Alternate Names

tnfrsf17,tnfrsf17 protein,human tnfrsf17 elisa,bcma,bcma ihc,bcma protein,bcma gene,bcma expression,bcma receptor,human bcma,recombinant bcma,human bcma elisa,Recombinant Protein,fc tag,fc tag protein,avi tag,avi tag protein,Human TNFRSF17 Protein

Official Symbol

TNFRSF17/BCMA

Species

Human

Expression Host

HEK293 Cells

Protein Family

TNF Receptor Superfamily

Product Description

ALP64524 Recombinant Human TNFRSF17 Protein, Fc Tag, Avi Tag is produced in HEK293 Cells and the target gene encoding Met1-Ala54 is expressed with a Fc, Avi tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Carpenter, R., Clin Cancer Res, 2013, DOI: 10.1158/1078-0432.CCR-13-1303

2 Cohen, A., J Clin Invest, 2019, DOI: 10.1172/JCI126397

3 Ali, S., Blood, 2016, DOI: 10.1182/blood-2015-10-673236

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