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Recombinant Human TNFRSF17/BCMA Protein, His Tag, Flag Tag

Protein

Recombinant Human TNFRSF17/BCMA Protein, His Tag, Flag Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: TNFRSF17

TNFRSF17 (TNF Receptor Superfamily Member 17) is a Protein Coding gene. Diseases associated with TNFRSF17 include Macroglobulinemia and Lymphoma. Among its related pathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation. Gene Ontology (GO) annotations related to this gene include signaling receptor activity. An important paralog of this gene is TNFRSF13C. Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.Promotes B-cell survival and plays a role in the regulation of humoral immunity.Activates NF-kappa-B and JNK.

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

B cell maturation antigen(BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid(aa) protein consisting of a 49 aa extracellular domain, a 23 aa transmembrane domain, and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation.

Product Specification

Catalog Number

ALP64513

Product Name

Recombinant Human TNFRSF17/BCMA Protein, His Tag, Flag Tag

Alias

CD269, Bcma

Alternate Names

tnfrsf17,tnfrsf17 protein,human tnfrsf17 elisa,bcma,bcma ihc,bcma protein,bcma gene,bcma expression,bcma receptor,human bcma,recombinant bcma,human bcma elisa,Recombinant Protein,his tag,his tag protein,flag tag,flag tagged protein,Human TNFRSF17 Protein,

Official Symbol

TNFRSF17/BCMA

Species

Human

Expression Host

HEK293 Cells

Protein Family

TNF Receptor Superfamily

Product Description

ALP64513 Recombinant Human TNFRSF17 Protein, His Tag, Flag Tag is produced in HEK293 Cells and the target gene encoding Met1-Ala54 is expressed with a 6His, Flag tag at the N-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Carpenter, R., Clin Cancer Res, 2013, DOI: 10.1158/1078-0432.CCR-13-1303

2 Cohen, A., J Clin Invest, 2019, DOI: 10.1172/JCI126397

3 Ali, S., Blood, 2016, DOI: 10.1182/blood-2015-10-673236

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