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Recombinant Human VSTM3/TIGIT/VSIG9 Protein, Fc Tag

Protein

Recombinant Human VSTM3/TIGIT/VSIG9 Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: VSTM3

TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains) is a Protein Coding gene. Diseases associated with TIGIT include Endocervical Carcinoma and Chromophobe Renal Cell Carcinoma. Among its related pathways are Interactions of natural killer cells in pancreatic cancer and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is CD226.Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.  

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

T cell immunoreceptor with Ig and ITIM domains(TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells(DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1.

Product Specification

Catalog Number

ALP64576

Product Name

Recombinant Human VSTM3/TIGIT/VSIG9 Protein, Fc Tag

Alias

T-cell immunoreceptor with Ig and ITIM domains,, VSIG9

Alternate Names

tigit,tigit ligand,tigit receptor,tigit inhibitor,tigit protein,tigit gene,VSTM3 protein,VSIG9 protein,Recombinant Protein,Human VSTM3 Protein,fc tag,fc tag protein

Official Symbol

VSTM3/TIGIT/VSIG9

Species

Human

Expression Host

HEK293 Cells

Protein Family

CD28 Family

Product Description

ALP64576 Recombinant Human VSTM3 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Met22-Pro141 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Joller, N., Hafler, J. P., Brynedal, B., Kassam, N., Spoerl, S., Levin, S. D., ... & Kuchroo, V. K., Journal of Immunology, 2011, DOI: 10.4049/jimmunol.1100139

2 Li, M., Xia, P., Du, Y., Liu, T., Wang, J., Zhang, W., ... & Tian, Z., Journal of Clinical Investigation, 2014, DOI: 10.1172/JCI80301

3 Lozano, E., Dominguez-Villar, M., Kuchroo, V., & Hafler, D. A., Journal of Immunology, 2012, DOI: 10.4049/jimmunol.1103627

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