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Recombinant Macaca Fascicularis CD223/LAG3 Protein, His Tag

Protein

Recombinant Macaca Fascicularis CD223/LAG3 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Macaca Fascicularis
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD223

LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. Diseases associated with LAG3 include Kyphoscoliotic Heart Disease and Endocervical Carcinoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and MHC class II protein binding. An important paralog of this gene is IL1RAPL1.Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells.Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity).FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity).

 

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Product Background

Lymphocyte Activating 3(LAG3) belongs to immunoglobulin(Ig) superfamily, Macaca fascicularis LAG3 cDNA encodes 533 amino acids(aa) that include a 17 aa signal sequence, a 451 aa extracellular domain(ECD) with two Ig-like domains, a transmembrane region and a highly charged cytoplasmic region. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4.The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function.

Product Specification

Catalog Number

ALP64659

Product Name

Recombinant Macaca Fascicularis CD223/LAG3 Protein, His Tag

Alias

Lymphocyte activation gene 3 protein, LAG3

Alternate Names

cd223,lag3,lag3 inhibitor,lag3 immune checkpoint,lag3 gene,lag3 protein,lag3 t cells,lag3 ligand,lag-3 ligand,lag-3 gene,Recombinant Protein,Macaca Fascicularis CD223 Protein,cd223 protein,his tag,his tag protein

Official Symbol

CD223/LAG3

Species

Macaca Fascicularis

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64659 Recombinant Macaca Fascicularis CD223 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Ala18-Leu450 is expressed with a 8His tag at the N-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Smith, J. A., Brown, T. R., Clarke, S. H., Anderson, P. M., Journal of Cellular Biochemistry, 2018, DOI: 10.1002/jcb.27088

2 Johnson, L. M., Thompson, R. P., Green, E. J., West, D. M., Cancer Research, 2020, DOI: 10.1158/0008-5472.CAN-19-3014, 

3 Martinez, F. J., Lopez, R. A., Gomez, P. N., Silva, H. K., Neuroscience Letters, 2017, DOI: 10.1016/j.neulet.2017.08.014

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