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Recombinant Mouse CD137/TNFRSF9/4-1BB Protein, Fc Tag

Protein

Recombinant Mouse CD137/TNFRSF9/4-1BB Protein, Fc Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD137

TNFRSF9 (TNF Receptor Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFRSF9 include Immunodeficiency 109 With Lymphoproliferation and B-Cell Lymphoma. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. Gene Ontology (GO) annotations related to this gene include signaling receptor activity and cytokine binding. An important paralog of this gene is TNFRSF21.Receptor for TNFSF9/4-1BBL.Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).

 

Alpha Lifetech utilizes different expression systems to produce recombinant proteins in E. coli, yeast, insect, mammalian cells, and cell-free expression systems to meet different needs.

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Product Background

Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor(TNF) receptor family. It can be induced by lymphocyte activation(ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.

Product Specification

Catalog Number

ALP64643

Product Name

Recombinant Mouse CD137/TNFRSF9/4-1BB Protein, Fc Tag

Alias

CD137, ILA

Alternate Names

cd137,cd137 agonist,cd137 ligand,cd137 gene,human cd137,cd137 protein,tnfrsf9,tnfrsf9 gene,human tnfrsf9 elisa,human tnfrsf9,4-1bb,4-1bb ligand,4-1bb gene,4-1bb agonist,human 4-1bb elisa,human 4-1bb ligand,Recombinant Protein,Mouse CD137 Protein,fc tag,fc tag protein

Official Symbol

CD137/TNFRSF9/4-1BB

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

TNF-receptor Superfamily

Product Description

ALP64643 Recombinant Mouse CD137 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Val24-Leu187 is expressed with a Fc tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM PB, 150mM NaCl, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Chester, C., Sanmamed, M. F., Wang, J., Melero, I., Sanmamed, M. F., Wang, J., Blood, 2016, DOI: 10.1182/blood-2015-09-667096

2 Pardoll, D. M., Nature Reviews Cancer, 2012, DOI: 10.1038/nrc3239

3 Kocak, E., Lute, K., Chang, X., May, K. F., Exten, K. R., Zhang, H., Abdessalam, S. F., Lehman, A. M., Jarjoura, D., Zheng, P., Liu, Y., Cancer Research, 2006, DOI: 10.1158/0008-5472.CAN-06-0995

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