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Recombinant Mouse CD137L/4-1BBL/TNFSF9 Protein, His Tag

Protein

Recombinant Mouse CD137L/4-1BBL/TNFSF9 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD137L

TNFSF9 (TNF Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFSF9 include Immunodeficiency 16 and Mouth Disease. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding.Cytokine that binds to TNFRSF9.Induces the proliferation of activated peripheral blood T-cells.May have a role in activation-induced cell death (AICD). 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

Tumor necrosis factor ligand superfamily member 9, also known as 4-1BBL, is a member of the the tumor necrosis factor family. Mouse 4-1BBL cDNA encodes a 309 amino acid residues(aa) protein with an 82 aa N-terminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C-terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that of other TNFSF members, but shares only low aa sequence homology(14-16%). 4-1BBL is predominantly expressed on activated antigen presenting cells(APCs) such as B cells, macrophages and dendritic cells(DCs). It is also expressed on most T and B lymphoma cell lines. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction.

Product Specification

Catalog Number

ALP64586

Product Name

Recombinant Mouse CD137L/4-1BBL/TNFSF9 Protein, His Tag

Alias

CD137L, TNFSF9

Alternate Names

cd137l,4-1bbl,4-1bbl gene,tnfsf9,4-1BB ligand,cd137l protein,4-1bbl protein,tnfsf9 protein,Recombinant Protein,Mouse CD137L Protein,his tag,his tag protein

Official Symbol

CD137L/4-1BBL/TNFSF9

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

TNF Superfamily

Product Description

ALP64586 Recombinant Mouse CD137L Protein, His Tag is produced in HEK293 Cells and the target gene encoding Arg104-Glu309 is expressed with a 10His tag at the N-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Shao, Z., Schwarz, H., Journal of Immunology, 2011, DOI: 10.4049/jimmunol.1001521

2 Shaikh, R. B., Santee, S., Granger, S. W., Butrovich, K., Cheung, T., Kronenberg, M., Cheroutre, H., Ware, C. F., Journal of Experimental Medicine, 2001, DOI: 10.1084/jem.20010809

3 Choi, B. K., Lee, D. Y., Lee, D. G., Kim, Y. H., Kim, S. H., Oh, H. S., Lee, S. J., Kwon, B. S., Journal of Immunology, 2010, DOI: 10.4049/jimmunol.1001637

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