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Recombinant Mouse CD150/SLAM Protein, His Tag

Protein

Recombinant Mouse CD150/SLAM Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD150

SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1) is a Protein Coding gene. Diseases associated with SLAMF1 include Measles and Subacute Sclerosing Panencephalitis. Among its related pathways are Toll-like receptor signaling pathway and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signaling receptor activity and antigen binding. An important paralog of this gene is LY9.Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family.SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. 

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

Signaling lymphocyte activation molecule(SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages. SLAM consists of a extracellular domain(ECD) with two Ig-like domains,transmembrane segment, and cytoplasmic domain with three immunoreceptor tyrosine switch motifs(ITSM). SLAM is thought to play an important role in adhesion between T cells and APCs and has been shown to act as a coreceptor in TCR-dependent responses. SLAM, together with CD46, is one of the two receptors for measles virus. SLAM is a cell surface receptor that, like the B cell receptor, CD40, and CD95, can transmit positive or negative signals. SLAM can associate with the SH2-containing inositol phosphatase(SHIP), the SH2-containing protein tyrosine phosphatase(SHP-2), and the adaptor protein SH2 domain protein 1A. It’s upregulated on activated B cells and CD4+ and CD8+ T cells, but downregulated on Th2 polarized cells. Also, it can Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4-/CD8- T-cells

Product Specification

Catalog Number

ALP64687

Product Name

Recombinant Mouse CD150/SLAM Protein, His Tag

Alias

Signaling Lymphocytic Activation Molecule, CD150

Alternate Names

cd150,cd150 marker,slam family,slam associated protein,slam receptor,slam seq,slam markers,Recombinant Protein,Mouse CD150 Protein,his tag,his tag protein

Official Symbol

CD150/SLAM

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

SLAM Family

Product Description

ALP64687 Recombinant Mouse CD150 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Thr25-Pro242 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Veillette, A., Dong, Z., Latour, S., Nature Reviews Immunology, 2007, DOI: 10.1038/nri1997

2 Boles, K. S., Mathew, P. A., Immunological Reviews, 2001, DOI: 10.1034/j.1600-065x.2001.1810106.x

3 Cocks, B. G., Chang, C. C., Carballido, J. M., Yssel, H., de Vries, J. E., Aversa, G., Nature, 1995, DOI: 10.1038/376260a0

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