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Recombinant Mouse CD152/CTLA-4 Protein, Flag Tag

Protein

Recombinant Mouse CD152/CTLA-4 Protein, Flag Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD152

CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) is a Protein Coding gene. Diseases associated with CTLA4 include Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation and Celiac Disease 3. Among its related pathways are Gene expression (Transcription) and CD28 co-stimulation. An important paralog of this gene is CD28.Inhibitory receptor acting as a major negative regulator of T-cell responses.The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. 

 

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Product Background

Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).

Product Specification

Catalog Number

ALP64582

Product Name

Recombinant Mouse CD152/CTLA-4 Protein, Flag Tag

Alias

Cytotoxic T-lymphocyte protein 4, CD152

Alternate Names

cd152,ctla4 cd152,ctla-4,ctla-4 inhibitors,ctla-4 inhibitor,ctla-4 receptor,ctla-4 gene,ctla-4 ligand,ctla-4 signaling pathway,ctla-4 expression,ctla-4 signaling,ctla-4 cancer,ctla-4 pathway,Recombinant Protein,cd152 protein,ctla-4 protein,Mouse CD152 Protein,flag tag,flag tagged protein

Official Symbol

CD152/CTLA-4

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64582 Recombinant Mouse CD152 Protein, Flag Tag is produced in HEK293 Cells and the target gene encoding Ala37-Asp161 is expressed with a Flag tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Krummel, M. F., and Allison, J. P., The Journal of Experimental Medicine, 1996, DOI: 10.1084/jem.183.6.2533

2 Chambers, C. A., et al.,Immunological Reviews, 1999, DOI: 10.1111/j.1600-065X.1999.tb01339.x

3 Walunas, T. L., et al., Immunity, 1994, DOI: 10.1016/1074-7613(94)90144-9

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