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Recombinant Mouse CD155/PVR Protein, His Tag

Protein

Recombinant Mouse CD155/PVR Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD155

PVR (PVR Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with PVR include Poliomyelitis and Paralytic Poliomyelitis. Among its related pathways are Cell junction organization and Innate Immune System. Gene Ontology (GO) annotations related to this gene include signaling receptor activity and virus receptor activity. An important paralog of this gene is NECTIN2.Mediates NK cell adhesion and triggers NK cell effector functions.Binds two different NK cell receptors: CD96 and CD226.These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell.

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

Mouse poliovirus receptor(PVR, CD155) is a type I transmembrane(TM) glycoprotein that is a member of the nectin-related family of adhesion proteins within the immunoglobulin superfamily. It binds other molecules including vitronectin, Nectin3, DNAM1, CD96, and TIGIT, but does not bind homotypically. CD155 includes a 28 aa signal sequence, a 318 aa extracellular domain(ECD) with one N-terminal V-type and two C2-type Ig-like domains, a 24 aa TM segment and a 38 aa cytoplasmic tail. Epithelial, endothelial, and many immune cells show low CD155 expression. It is up-regulated on endothelia by IFNγ, and is highly expressed on immature thymocytes, lymph node dendritic cells, and tumor cells of epithelial and neuronal origin. On migrating cells, it is concentrated at the leading edge, where it binds basement membrane vitronectin, recruits Nectin-3-expressing cells, and cooperates with PDGF and integrin αvβ3 to promote cell migration. Binding of monocyte DNAM-1 to endothelial cell CD155 promotes transendothelial migration. Enhanced CD155 expression in tumor cells contributes to loss of contact inhibition and increased migration, but also allows tumor cell recognition and killing by DNAM-1or CD96 expressing NK cells.

Product Specification

Catalog Number

ALP64590

Product Name

Recombinant Mouse CD155/PVR Protein, His Tag

Alias

Poliovirus Receptor, CD155

Alternate Names

cd155,tigit cd155,cd155 receptor,pvr cd155,cd155 gene,cd155 expression,pvr research,pvr gene,pvr tigit,recombinant pvr,pvr protein,Mouse CD155 Protein,Recombinant Protein,his tag,his tag protein

Official Symbol

CD155/PVR

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64590 Recombinant Mouse CD155 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Asp29-Leu348 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Masson, D., Jarry, A., Baury, B., Blanchardie, P., Laboisse, C. L., Lustenberger, P., Tréhoux, A., Lévêque, J., Denis, M. G., Lustenberger, P., Gut, 2001, DOI: 10.1136/gut.49.2.236

2 Moulin, V., Andris, F., Thielemans, K., Maliszewski, C., Urbain, J., Moser, M., European Journal of Immunology, 1996, DOI: 10.1002/eji.1830261105

3 Koike, S., Horie, H., Ise, I., Okitsu, A., Yoshida, M., Iizuka, N., Takeuchi, K., Nomoto, A., Immunogenetics, 1995, 10.1007/BF00172442

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