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Recombinant Mouse CD160 Protein, His Tag

Protein

Recombinant Mouse CD160 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD160

CD160 (CD160 Molecule) is a Protein Coding gene. Diseases associated with CD160 include Folliculitis and Kummell's Disease. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and MHC class I receptor activity.[CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation.Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells.Receptor for both classical and non-classical MHC class I molecules. 

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult.

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Product Background

CD160 antigen is a cell membrane protein which contains one Ig-likeV-type(immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim) CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and smal lintestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.

Product Specification

Catalog Number

ALP64671

Product Name

Recombinant Mouse CD160 Protein, His Tag

Alias

CD160 antigen, CD160

Alternate Names

cd160,cd160 gene,Recombinant Protein,cd160 protein,Mouse CD160 Protein,his tag,his tag protein

Official Symbol

CD160

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64671 Recombinant Mouse CD160 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Gly28-Ser160 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Nguyen, T., Mitchell, T. C., Niro, J., Schaeffer, E. L., Choi, K., Journal of Immunology, 2005, DOI: 10.4049/jimmunol.174.8.4429

2 Nguyen, T., Mitchell, T. C., Niro, J., Schaeffer, E. L., Choi, K., Journal of Experimental Medicine, 2012, DOI: 10.1084/jem.20112345

3 Barak, Y., Cohen, M. H., Tsang, K. Y., Luster, A. D., Nature Immunology, 2006, DOI: 10.1038/ni1327

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