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Recombinant Mouse CD172a/SHPS-1/SIRPA Protein, MIgG2a Tag

Protein

Recombinant Mouse CD172a/SHPS-1/SIRPA Protein, MIgG2a Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD172a

SIRPA (Signal Regulatory Protein Alpha) is a Protein Coding gene. Diseases associated with SIRPA include Hyperglycemia and Glioblastoma. Among its related pathways are Innate Immune System and Cell junction organization. Gene Ontology (GO) annotations related to this gene include SH3 domain binding. An important paralog of this gene is SIRPB1.Immunoglobulin-like cell surface receptor for CD47.
Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane.
Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.

 

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Product Background

SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.

Product Specification

Catalog Number

ALP64598

Product Name

Recombinant Mouse CD172a/SHPS-1/SIRPA Protein, MIgG2a Tag

Alias

CD172a, SHPS-1,SIRPA

Alternate Names

cd172a,sirpa expression,sirpa gene,sirpa protein,sirpa,sirp alpha,Recombinant Protein,cd172a protein,Mouse CD172a Protein

Official Symbol

CD172a/SHPS-1/SIRPA

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64598 Recombinant Mouse CD172a Protein, MIgG2a Tag is produced in HEK293 Cells and the target gene encoding Lys32-Asn373 is expressed with a MIgG2a tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Takahashi, S., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Gilbert, D. J., Shapiro, L. H., Fujita, T., Bock, C. B., O'Brien, D. P., Saito, T., McVicar, D. W., Ihle, J. N., Proceedings of the National Academy of Sciences, 1999, DOI: 10.1073/pnas.96.6.3115

2 Matozaki, T., Murata, Y., Okazawa, H., Ohnishi, H., Trends in Cell Biology, 2009, DOI: 10.1016/j.tcb.2009.07.004

3 Alvey, C. M., Discher, D. E., Current Opinion in Immunology, 2017, DOI: 10.1016/j.coi.2017.07.007

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