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Recombinant Mouse CD223/LAG3 Protein, His Tag

Protein

Recombinant Mouse CD223/LAG3 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD223

LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. Diseases associated with LAG3 include Kyphoscoliotic Heart Disease and Endocervical Carcinoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and MHC class II protein binding. An important paralog of this gene is IL1RAPL1.Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells.Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity).FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity).

 

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Product Background

Lymphocyte-activation gene 3(LAG3), also known as CD223, is a type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4 and belongs to the immunoglobulin superfamily. The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene. LAG3 is expressed on activated T cells, natural killer cells, B cells and plasmacytoid dendritic cells. LAG3 binds with high affinity to MHC class II molecules, and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and plays an important role in Treg suppressive function. LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders. The soluble form, sLAG-3, is being developed as a cancer drug.

Product Specification

Catalog Number

ALP64611

Product Name

Recombinant Mouse CD223/LAG3 Protein, His Tag

Alias

Lymphocyte activation gene 3 protein, LAG3

Alternate Names

cd223,lag3,lag3 inhibitor,lag3 immune checkpoint,lag3 gene,lag3 protein,lag3 t cells,lag3 ligand,lag-3 ligand,lag-3 gene,Recombinant Protein,Mouse CD223 Protein,cd223 protein,his tag,his tag protein

Official Symbol

CD223/LAG3

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64611 Recombinant Mouse CD223 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Ser23-Leu442 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Smith, J. A., Brown, T. R., Clarke, S. H., Anderson, P. M., Journal of Cellular Biochemistry, 2018, DOI: 10.1002/jcb.27088

2 Johnson, L. M., Thompson, R. P., Green, E. J., West, D. M., Cancer Research, 2020, DOI: 10.1158/0008-5472.CAN-19-3014, 

3 Martinez, F. J., Lopez, R. A., Gomez, P. N., Silva, H. K., Neuroscience Letters, 2017, DOI: 10.1016/j.neulet.2017.08.014

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