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Recombinant Mouse CD244/2B4/SLAMF4 Protein, His Tag

Protein

Recombinant Mouse CD244/2B4/SLAMF4 Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Mouse
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD244

CD244 (CD244 Molecule) is a Protein Coding gene. Diseases associated with CD244 include Tuberculosis and Rheumatoid Arthritis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Lymphoid Cells Differentiation. Gene Ontology (GO) annotations related to this gene include signaling receptor activity. An important paralog of this gene is SLAMF7.Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48.SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. 

 

Alpha Lifetech specializes in producing high-quality recombinant proteins to ensure purity and activity for various research applications.

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Product Background

Natural killer cell receptor 2B4(2B4/CD244)is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family. SLAM family proteins have an extracellular domain(ECD) with two or four Ig-like domains and at least two cytoplasmic immunoreceptor tyrosine-based switch motifs(ITSMs). 2B4 interacts with CD48, while other SLAM family proteins interact in a homophilic manner. The mouse 2B4 cDNA encodes a 397 amino acid(aa) precursor that includes a 19 aa signal sequence, a 207 aa ECD with one Ig-like V-type and one C2-type Ig-like domain, a 21 aa transmembrane segment, and a 150 aa cytoplasmic domain with four ITSMs. Within the ECD, mouse 2B4 shares 46% and 68% aa sequence identity with human and rat 2B4, respectively. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can directly trigger inhibitory signaling or disrupt an inhibitory interaction, leading to cellular activation. 2B4 can also induce signaling through CD48.

Product Specification

Catalog Number

ALP64686

Product Name

Recombinant Mouse CD244/2B4/SLAMF4 Protein, His Tag

Alias

Natural killer cell receptor 2B4, CD244

Alternate Names

cd244,cd244 gene,cd244 elisa,human cd244 elisa,human 2b4 elisa,2b4,2b4 gene,CD244 protein,2b4 protein,Recombinant Protein,his tag,his tag protein,Mouse CD244 Protein

Official Symbol

CD244/2B4/SLAMF4

Species

Mouse

Expression Host

HEK293 Cells

Protein Family

SLAM Family

Product Description

ALP64686 Recombinant Mouse CD244 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Gln20-Asn221 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Waggoner, S. N., Kumar, V., Frontiers in Immunology, 2012, DOI: 10.3389/fimmu.2012.00377

2 McNerney, M. E., Lee, K. M., Kumar, V., Journal of Immunology, 2005, DOI: 10.4049/jimmunol.175.7.4211

3 Chen, B. J., Cai, Q., Zhao, Q., Gu, J., Reese, J. S., Field, E. H., Liu, C., Journal of Clinical Investigation, 2008, DOI: 10.1172/JCI35062

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